Recombinant Human Pre-mRNA-processing factor 6 (PRPF6), Truncated

Uniprot Id

O94906

Target Species

Human

Target Name

PRPF6

Target Full Name

Pre-mRNA-processing factor 6

Target Function

Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation.

Target Involvement

Retinitis pigmentosa 60 (RP60)

Target Subcellular Location

Nucleus, nucleoplasm. Nucleus speckle.

Target Tissue Specificity

Widely expressed.

Target Synonyms

Androgen receptor N terminal domain transactivating protein 1; ANT 1; ANT1; C20orf14; hPrp6; p102 U5 small nuclear ribonucleoprotein particle binding protein; pre-mRNA processing factor 6; Pre-mRNA-processing factor 6; PRP6 homolog; PRP6 pre mRNA processing factor 6 homolog; PRP6_HUMAN; PRPF6; Putative mitochondrial outer membrane protein import receptor; TOM; U5 snRNP-associated 102 kDa protein; U5-102 kDa protein; U5-102K

Target Background

The protein encoded by this gene appears to be involved in pre-mRNA splicing, possibly acting as a bridging factor between U5 and U4/U6 snRNPs in formation of the spliceosome. The encoded protein also can bind androgen receptor, providing a link between transcriptional activation and splicing.