Home Products Recombinant Human Pregnancy zone protein (PZP), Truncated

Recombinant Human Pregnancy zone protein (PZP), Truncated

ACP03902

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Specifications

Cat.No	ACP03902	Target Name	PZP
Target Synonyms	PZP; CPAMD6; Pregnancy zone protein; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6	Form	Liquid or Lyophilized powder
Expression System	Yeast	Expression Range	472-821aa
Mol Weight	65.3kDa	Protein Length	Partial of Isoform 2
Purity	Greater than 90% as determined by SDS-PAGE.	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	P20742

Background Information

Uniprot Id

P20742
Target Species

Human
Target Name

PZP
Target Full Name

Pregnancy zone protein
Target Function

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
Target Subcellular Location

Secreted.
Target Protein Families

Protease inhibitor I39 (alpha-2-macroglobulin) family
Target Tissue Specificity

Plasma. Prominent constituent of late-pregnancy sera.
Target Research Area

Neuroscience
Target Synonyms

PZP; CPAMD6; Pregnancy zone protein; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6

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Recombinant Human Pregnancy zone protein (PZP), Truncated

Specifications

Immunogen Information

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