Recombinant Human Probable ATP-dependent RNA helicase DDX56 (DDX56)

Uniprot Id

Q9NY93

Target Species

Human

Target Name

DDX56

Target Full Name

Probable ATP-dependent RNA helicase DDX56

Target Function

May play a role in later stages of the processing of the pre-ribosomal particles leading to mature 60S ribosomal subunits. Has intrinsic ATPase activity.

Target Subcellular Location

Nucleus, nucleolus.

Target Protein Families

DEAD box helicase family, DDX56/DBP9 subfamily

Target Tissue Specificity

Detected in heart, brain, liver, pancreas, placenta and lung.

Target Synonyms

61 kd nucleolar helicase; ATP-dependent 61 kDa nucleolar RNA helicase; DDX21; DDX26; Ddx56; DDX56_HUMAN; DEAD (Asp-Glu-Ala-Asp) box helicase 56; DEAD (Asp-Glu-Ala-Asp) box polypeptide 56; DEAD box protein 21; DEAD box protein 56; DEAD box RNA helicase; DEAD/H box 56; NOH61; Nucleolar helicase of 61 kDa; Probable ATP-dependent RNA helicase DDX56; Putative nucleolar RNA helicase

Target Background

This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene shows ATPase activity in the presence of polynucleotides and associates with nucleoplasmic 65S preribosomal particles. This gene may be involved in ribosome synthesis, most likely during assembly of the large 60S ribosomal subunit. Multiple transcript variants encoding different isoforms have been found for this gene.