Recombinant Human Probable phospholipid-transporting ATPase IIA (ATP9A), Truncated

Uniprot Id

O75110

Target Species

Human

Target Name

ATP9A

Target Full Name

Probable phospholipid-transporting ATPase IIA

Target Function

Plays a role in regulating membrane trafficking of cargo proteins, namely endosome to plasma membrane recycling and endosome to trans-Golgi network retrograde transport. In complex with MON2 and DOP1B, regulates SNX3 retromer-mediated endosomal sorting of WLS, a transporter of Wnt morphogens in developing tissues. Participates in the formation of endosomal carriers that direct WLS trafficking back to Golgi, away from lysosomal degradation. Appears to be implicated in intercellular communication by negatively regulating the release of exosomes. The flippase activity towards membrane lipids and its role in membrane asymmetry remains to be proved.

Target Subcellular Location

Early endosome membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Target Protein Families

Cation transport ATPase (P-type) (TC 3.A.3) family, Type IV subfamily

Target Synonyms

ATP 9A; Atp9a; ATP9A_HUMAN; ATPase class II type 9A; ATPase IIA; ATPase type IV phospholipid transporting (P type); ATPase type IV phospholipid transporting (P type)(putative); ATPIIA; KIAA0611; Phospholipid transporting ATPase IIA; Probable phospholipid transporting ATPase IIA; Probable phospholipid-transporting ATPase IIA