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| Cat.No | ACP05342 | Target Name | ATP10B |
|---|---|---|---|
| Target Synonyms | ATP10B; ATPVB; KIAA0715Probable phospholipid-transporting ATPase VB; EC 7.6.2.1; ATPase class V type 10B; P4-ATPase flippase complex alpha subunit ATP10B | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O94823 |
|---|
Uniprot Id
O94823
Target Species
Human
Target Name
ATP10B
Target Full Name
Phospholipid-transporting ATPase VB
Target Function
Catalytic component of a P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of glucosylceramide (GlcCer) from the outer to the inner leaflet of lysosome membranes. Plays an important role in the maintenance of lysosome membrane integrity and function in cortical neurons.
Target Subcellular Location
Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B.
Target Protein Families
Cation transport ATPase (P-type) (TC 3.A.3) family, Type IV subfamily
Target Tissue Specificity
Expressed in predominantly in brain structures including medulla oblongata, substantia nigra and basal ganglia. Expressed in the gastrointestinal system with highest levels in the small intestine and colon. Also expressed at low levels in testis and thymu
Target Synonyms
ATP10B; ATPVB; KIAA0715Probable phospholipid-transporting ATPase VB; EC 7.6.2.1; ATPase class V type 10B; P4-ATPase flippase complex alpha subunit ATP10B
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