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| Cat.No | ACP07271 | Target Name | SRD5A3 |
|---|---|---|---|
| Target Synonyms | SRD5A3; SRD5A2L; Polyprenol reductase; 3-oxo-5-alpha-steroid 4-dehydrogenase 3; Steroid 5-alpha-reductase 2-like; Steroid 5-alpha-reductase 3; S5AR 3; SR type 3 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9H8P0 |
|---|
Uniprot Id
Q9H8P0
Target Species
Human
Target Name
SRD5A3
Target Full Name
Polyprenal reductase
Target Function
Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT).
Target Involvement
Congenital disorder of glycosylation 1Q (CDG1Q); Kahrizi syndrome (KHRZ)
Target Subcellular Location
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Target Protein Families
Steroid 5-alpha reductase family, Polyprenol reductase subfamily
Target Tissue Specificity
Expressed in preadipocytes (at protein level). Overexpressed in hormone-refractory prostate cancers (HRPC). Almost no or little expression in normal adult organs.
Target Synonyms
SRD5A3; SRD5A2L; Polyprenol reductase; 3-oxo-5-alpha-steroid 4-dehydrogenase 3; Steroid 5-alpha-reductase 2-like; Steroid 5-alpha-reductase 3; S5AR 3; SR type 3
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