Chinese (Simplified)
English
German
Korean
Spanish
Sign up for an account to enjoy easy online shopping and instant order tracking.
| Cat.No | ACP10889 | Target Name | THG1L |
|---|---|---|---|
| Target Synonyms | THG1L; ICF45; Probable tRNA(His) guanylyltransferase; EC 2.7.7.79; Interphase cytoplasmic foci protein 45; tRNA-histidine guanylyltransferase | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-298 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9NWX6 |
|---|
Uniprot Id
Q9NWX6
Target Species
Human
Target Name
THG1L
Target Full Name
Probable tRNA(His) guanylyltransferase
Target Function
Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis (Probable). Also functions as a guanyl-nucleotide exchange factor/GEF for the MFN1 and MFN2 mitofusins thereby regulating mitochondrial fusion. By regulating both mitochondrial dynamics and bioenergetic function, it contributes to cell survival following oxidative stress.
Target Subcellular Location
Cytoplasm. Mitochondrion outer membrane.
Target Protein Families
TRNA(His) guanylyltransferase family
Target Tissue Specificity
Expressed in many tissues.
Target Synonyms
THG1L; ICF45; Probable tRNA(His) guanylyltransferase; EC 2.7.7.79; Interphase cytoplasmic foci protein 45; tRNA-histidine guanylyltransferase
Free shipping on orders $999+
Advenit post multos Scudilo Scutariorum tribunus velament
We accept credit cards, PayPal, and bank wires
Responsive and knowledgable customer service via email, text or phone
Notification
