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The recombinant Human PIBF1 was expressed with the amino acid range of 1-757. This PIBF1 protein is theoretically predicted to have a molecular weight of 97.2 kDa. The PIBF1 protein was expressed in e.coli. The N-terminal 10xHis tag and C-terminal Myc tag was fused into the coding gene segment of PIBF1, making it easier to detect and purify the PIBF1 recombinant protein in the later stages of expression and purification.Human progesterone-induced-blocking factor 1 (PIBF1) plays a pivotal role in immune modulation during pregnancy. Its main function involves promoting immune tolerance at the maternal-fetal interface, protecting the developing embryo from rejection. In reproductive and immunological research, studying PIBF1 provides crucial insights into maternal immune adaptation and fetal protection mechanisms. PIBF1's involvement in reproductive disorders and immune-related conditions suggests potential applications in fertility treatments and autoimmune disease research. Investigating PIBF1 contributes to a comprehensive understanding of immune regulation during pregnancy and opens avenues for therapeutic strategies in reproductive health and immunology, addressing challenges in maternal-fetal tolerance and autoimmune disorders.
The recombinant Human PIBF1 was expressed with the amino acid range of 1-757. This PIBF1 protein is theoretically predicted to have a molecular weight of 97.2 kDa. The PIBF1 protein was expressed in e.coli. The N-terminal 10xHis tag and C-terminal Myc tag was fused into the coding gene segment of PIBF1, making it easier to detect and purify the PIBF1 recombinant protein in the later stages of expression and purification.Human progesterone-induced-blocking factor 1 (PIBF1) plays a pivotal role in immune modulation during pregnancy. Its main function involves promoting immune tolerance at the maternal-fetal interface, protecting the developing embryo from rejection. In reproductive and immunological research, studying PIBF1 provides crucial insights into maternal immune adaptation and fetal protection mechanisms. PIBF1’s involvement in reproductive disorders and immune-related conditions suggests potential applications in fertility treatments and autoimmune disease research. Investigating PIBF1 contributes to a comprehensive understanding of immune regulation during pregnancy and opens avenues for therapeutic strategies in reproductive health and immunology, addressing challenges in maternal-fetal tolerance and autoimmune disorders.
| Cat.No | ACP04978 | Target Name | PIBF1 |
|---|---|---|---|
| Target Synonyms | PIBF1; C13orf24; PIBF; Progesterone-induced-blocking factor 1; Centrosomal protein of 90 kDa; CEP90 | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 1-757aa |
| Mol Weight | 97.2 kDa | Protein Length | Full length |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8WXW3 |
|---|
Uniprot Id
Q8WXW3
Target Species
Human
Target Name
PIBF1
Target Full Name
Progesterone-induced-blocking factor 1
Target Function
Plays a role in ciliogenesis.; Pericentriolar protein required to maintain mitotic spindle pole integrity. Required for the centrosomal accumulation of PCM1 and the recruitment of centriolar satellite proteins such as BBS4. Via association with PCM1 may be involved in primary cilia formation. Required for CEP63 centrosomal localization and its interaction with WDR62. Together with CEP63 promotes centriole duplication. Promotes the centrosomal localization of CDK2.; The secreted form is a mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling decidual naturakl killer cells (NK) activity exerts an anti-abortive effect. Increases the production of Th2-type cytokines by signaling via the JAK/STAT pathway. Activates STAT6 and inhibits STAT4 phosphorylation. Signaling via a not identified receptor seems to implicate IL4R and a GPI-anchored protein.
Target Involvement
May be associated with microcephaly.
Target Subcellular Location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Secreted.; [Isoform 1]: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Secreted.; [Isoform 4]: Secreted.
Target Tissue Specificity
Expressed at highest levels in testis. Moderate expression is detected in spleen, thymus, prostate, ovary, small intestine, and colon. Expressed in the first trimester pregnancy decidua. Localized to extravillous cytotrophoblast (at protein level). Also f
Target Research Area
Cell Biology
Target Synonyms
PIBF1; C13orf24; PIBF; Progesterone-induced-blocking factor 1; Centrosomal protein of 90 kDa; CEP90
Target Background
This gene encodes a protein that is induced by the steroid hormone progesterone and plays a role in the maintenance of pregnancy. The encoded protein regulates multiple facets of the immune system to promote normal pregnancy including cytokine synthesis, natural killer (NK) cell activity, and arachidonic acid metabolism. Low serum levels of this protein have been associated with spontaneous pre-term labor in humans. This protein may promote the proliferation, migration and invasion of glioma.
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