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| Cat.No | ACP22458 | Target Name | GNRH1 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 24-92 | Protein Length | Full Length of Mature Protein |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P01148 |
|---|
Uniprot Id
P01148
Target Species
Human
Target Name
GNRH1
Target Full Name
Progonadoliberin-1
Target Function
Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.
Target Involvement
Hypogonadotropic hypogonadism 12 with or without anosmia (HH12)
Target Subcellular Location
Secreted.
Target Protein Families
GnRH family
Target Synonyms
GNRH1; GNRH; GRH; LHRHProgonadoliberin-1; Progonadoliberin I) [Cleaved into: Gonadoliberin-1; Gonadoliberin I; Gonadorelin; Gonadotropin-releasing hormone I; GnRH-I; Luliberin I; Luteinizing hormone-releasing hormone I; LH-RH I); GnRH-associated peptide 1; GnRH-associated peptide I)]
Target Background
This gene encodes a preproprotein that is proteolytically processed to generate a peptide that is a member of the gonadotropin-releasing hormone (GnRH) family of peptides. Alternative splicing results in multiple transcript variants, at least one of which is secreted and then cleaved to generate gonadoliberin-1 and GnRH-associated peptide 1. Gonadoliberin-1 stimulates the release of luteinizing and follicle stimulating hormones, which are important for reproduction. Mutations in this gene are associated with hypogonadotropic hypogonadism.
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