Recombinant Human Prokineticin-2 (PROK2)

Uniprot Id

Q9HC23

Target Species

Human

Target Name

PROK2

Target Full Name

Prokineticin-2

Target Function

May function as an output molecule from the suprachiasmatic nucleus (SCN) that transmits behavioral circadian rhythm. May also function locally within the SCN to synchronize output. Potently contracts gastrointestinal (GI) smooth muscle.

Target Involvement

Hypogonadotropic hypogonadism 4 with or without anosmia (HH4)

Target Subcellular Location

Secreted.

Target Protein Families

AVIT (prokineticin) family

Target Tissue Specificity

Expressed in the testis and, at low levels, in the small intestine.

Target Synonyms

BV8; Bv8 homolog ; MIT1 ; PK2; PROK2; PROK2_HUMAN; Prokineticin-2; Protein Bv8 homolog

Target Background

This gene encodes a protein expressed in the suprachiasmatic nucleus (SCN) circadian clock that may function as the output component of the circadian clock. The secreted form of the encoded protein may also serve as a chemoattractant for neuronal precursor cells in the olfactory bulb. Proteins from other vertebrates which are similar to this gene product were isolated based on homology to snake venom and secretions from frog skin, and have been shown to have diverse functions. Mutations in this gene are associated with Kallmann syndrome 4. Multiple transcript variants encoding different isoforms have been found for this gene.