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Recombinant Human Proline-rich nuclear receptor coactivator 2 (PNRC2)

ACP19078

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Specifications

Cat.No	ACP19078	Target Name	PNRC2
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Expression Range	1-139	Protein Length	Full length protein
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q9NPJ4

Background Information

Uniprot Id

Q9NPJ4
Target Species

Human
Target Name

PNRC2
Target Full Name

Proline-rich nuclear receptor coactivator 2
Target Function

Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs. Required for UPF1/RENT1 localization to the P-body. Plays a role in glucocorticoid receptor-mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand-dependent manner when it is bound to the 5' UTR of target mRNAs and recruiting the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay. Also acts as a nuclear receptor coactivator. May play a role in controlling the energy balance between energy storage and energy expenditure.
Target Subcellular Location

Nucleus. Cytoplasm, P-body.
Target Protein Families

PNRC family, PNRC2 subfamily
Target Tissue Specificity

Expressed in heart, lung, muscle and brain.
Target Synonyms

0610011E17Rik; D4Bwg0593e; FLJ20312; MGC11707; MGC93828; MGC99541; OTTMUSP00000010360; OTTMUSP00000010366; pnrc2; PNRC2_HUMAN; Proline rich nuclear receptor coactivator 2; Proline-rich nuclear receptor coactivator 2; RP11-4M23.5; RP23-161N17.3
Target Background

Involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Located in Golgi apparatus; P-body; and nucleoplasm.

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Recombinant Human Proline-rich nuclear receptor coactivator 2 (PNRC2)

Specifications

Immunogen Information

Inquire Recombinant Human Proline-rich nuclear receptor coactivator 2 (PNRC2) Now

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