Chinese (Simplified)
English
German
Korean
Spanish
Sign up for an account to enjoy easy online shopping and instant order tracking.
The recombinant Human P4HA1 was expressed with the amino acid range of 18-534. The calculated molecular weight for this P4HA1 protein is 63.1 kDa. This protein is generated in a e.coli-based system. The P4HA1 coding gene included the N-terminal 6xHis tag, which simplifies the detection and purification processes of the recombinant P4HA1 protein in following stages of expression and purification.The human prolyl 4-hydroxylase subunit alpha-1 (P4HA1) is a key component of the prolyl 4-hydroxylase enzyme complex, which plays a critical role in the post-translational modification of collagen. P4HA1 specifically catalyzes the hydroxylation of proline residues in collagen, contributing to the stability and structure of this essential extracellular matrix protein. This enzymatic modification is crucial for collagen's proper folding and function. Collagen, in turn, is a major structural protein in connective tissues, providing strength and support to various tissues and organs in the body. Research on P4HA1 often delves into understanding collagen biosynthesis, tissue development, and the role of collagen in health and diseases, including fibrosis and cancer. Additionally, investigations may explore therapeutic strategies targeting collagen-related disorders by modulating P4HA1 activity.
The recombinant Human P4HA1 was expressed with the amino acid range of 18-534. The calculated molecular weight for this P4HA1 protein is 63.1 kDa. This protein is generated in a e.coli-based system. The P4HA1 coding gene included the N-terminal 6xHis tag, which simplifies the detection and purification processes of the recombinant P4HA1 protein in following stages of expression and purification.The human prolyl 4-hydroxylase subunit alpha-1 (P4HA1) is a key component of the prolyl 4-hydroxylase enzyme complex, which plays a critical role in the post-translational modification of collagen. P4HA1 specifically catalyzes the hydroxylation of proline residues in collagen, contributing to the stability and structure of this essential extracellular matrix protein. This enzymatic modification is crucial for collagen’s proper folding and function. Collagen, in turn, is a major structural protein in connective tissues, providing strength and support to various tissues and organs in the body. Research on P4HA1 often delves into understanding collagen biosynthesis, tissue development, and the role of collagen in health and diseases, including fibrosis and cancer. Additionally, investigations may explore therapeutic strategies targeting collagen-related disorders by modulating P4HA1 activity.
| Cat.No | ACP03652 | Target Name | P4HA1 |
|---|---|---|---|
| Target Synonyms | 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), 2-oxoglutarate-4-dioxygenase subunit alpha-1; 4-hydroxylase, alpha I subunit; 4-PH alpha-1; P4HA; P4HA1; P4HA1_HUMAN; Procollagen-proline; Procollagen-proline, alpha polypeptide I; Prolyl 4-hydroxylase subunit alpha-1 | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 18-534aa |
| Mol Weight | 64.4 kDa | Protein Length | Full Length of Mature Protein |
| Purity | Greater than 85% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P13674 |
|---|
Uniprot Id
P13674
Target Species
Human
Target Name
P4HA1
Target Full Name
Prolyl 4-hydroxylase subunit alpha-1
Target Function
Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
Target Subcellular Location
Endoplasmic reticulum lumen.
Target Protein Families
P4HA family
Target Research Area
Signal Transduction
Target Synonyms
2-oxoglutarate-4-dioxygenase subunit alpha-1; 4-hydroxylase, alpha I subunit; 4-PH alpha-1; P4HA; P4HA1; P4HA1_HUMAN; Procollagen-proline; Procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I; Prolyl 4-hydroxylase subunit alpha-1
Target Background
This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described.
Free shipping on orders $999+
Advenit post multos Scudilo Scutariorum tribunus velament
We accept credit cards, PayPal, and bank wires
Responsive and knowledgable customer service via email, text or phone
Notification
