Recombinant Human Prostaglandin-H2 D-isomerase (PTGDS)

The expression region of this recombinant Human PTGDS covers amino acids 23-190. The calculated molecular weight for this PTGDS protein is 34.7 kDa. Expression of this PTGDS protein is conducted in e.coli. The PTGDS coding gene included the N-terminal 6xHis-SUMO tag, which simplifies the detection and purification processes of the recombinant PTGDS protein in following stages of expression and purification.Prostaglandin-H2 D-isomerase (PTGDS) is an enzyme involved in the biosynthesis of prostaglandin D2 (PGD2). PTGDS belongs to the lipocalin protein family and is primarily expressed in the central nervous system, particularly in the brain and cerebrospinal fluid. The main function of PTGDS is the isomerization of PGH2 to PGD2, which plays a role in various physiological processes, including inflammation and sleep regulation. PGD2 is associated with sleep-wake cycles, and PTGDS has been implicated in sleep-related functions. Additionally, PTGDS has been studied in the context of neuroinflammation, and neurodegenerative diseases, and as a potential biomarker for certain neurological conditions. Understanding the role of PTGDS in prostaglandin metabolism and its broader implications in neurological processes is essential for unraveling its potential therapeutic applications and furthering knowledge of neurobiology.

ACP02510

Number

Cat.No	ACP02510	Target Name	PTGDS
Form	Liquid or Lyophilized powder	Expression System	E.coli
Expression Range	23-190aa	Mol Weight	34.7kDa
Protein Length	Full Length of Mature Protein	Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP02510

Target Name

PTGDS

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

23-190aa

Mol Weight

34.7kDa

Protein Length

Full Length of Mature Protein

Purity

Greater than 90% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	P41222

Background Information

Uniprot Id

P41222
Target Species

Human
Target Name

PTGDS
Target Full Name

Prostaglandin-H2 D-isomerase
Target Function

Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system. Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR.
Target Subcellular Location

Rough endoplasmic reticulum. Nucleus membrane. Golgi apparatus. Cytoplasm, perinuclear region. Secreted. Note=Detected on rough endoplasmic reticulum of arachnoid and menigioma cells. Localized to the nuclear envelope, Golgi apparatus, secretory vesicles and spherical cytoplasmic structures in arachnoid trabecular cells, and to circular cytoplasmic structures in meningeal macrophages and perivascular microglial cells. In oligodendrocytes, localized to the rough endoplasmic reticulum and nuclear envelope. In retinal pigment epithelial cells, localized to distinct cytoplasmic domains including the perinuclear region. Also secreted.
Target Protein Families

Calycin superfamily, Lipocalin family
Target Tissue Specificity

Abundant in the brain and CNS, where it is expressed in tissues of the blood-brain barrier and secreted into the cerebro-spinal fluid. Abundantly expressed in the heart. In the male reproductive system, it is expressed in the testis, epididymis and prosta
Target Research Area

Metabolism
Target Synonyms

Beta trace protein; Beta-trace protein; Cerebrin 28; Cerebrin-28; glutathione independent PGD synthase; Glutathione independent PGD synthetase; Glutathione-independent PGD synthase; L PGDS; Lipocalin type prostaglandin D synthase; Lipocalin-type prostaglandin-D synthase; LPGDS; PDS; PGD2; PGD2 synthase; PGDS; PGDS2; prostaglandin D synthase; prostaglandin D2 synthase (21 kDa; brain); prostaglandin D2 synthase (brain); prostaglandin D2 synthase 21kDa (brain); Prostaglandin D2 synthase; prostaglandin H2 D isomerase; Prostaglandin-D2 synthase; Prostaglandin-H2 D-isomerase; PTGDS; PTGDS_HUMAN; RP23-47P18.11-006
Target Background

The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep.

Recombinant Human Prostaglandin-H2 D-isomerase (PTGDS)

Specifications

Immunogen Information

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