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| Cat.No | ACP19098 | Target Name | PAAF1 |
|---|---|---|---|
| Target Synonyms | PAAF1; WDR71Proteasomal ATPase-associated factor 1; Protein G-16; WD repeat-containing protein 71 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 2-392 |
| Protein Length | Full Length of Mature Protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9BRP4 |
|---|
Uniprot Id
Q9BRP4
Target Species
Human
Target Name
PAAF1
Target Full Name
Proteasomal ATPase-associated factor 1
Target Function
Inhibits proteasome 26S assembly and proteolytic activity by impairing the association of the 19S regulatory complex with the 20S core. In case of HIV-1 infection, recruited by viral Tat to the HIV-1 promoter, where it promotes the recruitment of 19S regulatory complex through dissociation of the proteasome 26S. This presumably promotes provirus transcription efficiency. Protects SUPT6H from proteasomal degradation.
Target Protein Families
WD repeat PAAF1/RPN14 family
Target Tissue Specificity
Ubiquitously expressed, with highest levels in kidney, brain and testis.
Target Synonyms
PAAF1; WDR71Proteasomal ATPase-associated factor 1; Protein G-16; WD repeat-containing protein 71
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