Recombinant Human Proteasome subunit alpha type-7-like (PSMA8)

Uniprot Id

Q8TAA3

Target Species

Human

Target Name

PSMA8

Target Full Name

Proteasome subunit alpha-type 8

Target Function

Component of the spermatoproteasome, a proteasome specifically found in testis that promotes acetylation-dependent degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. The proteasome is a protein complexe that degrades unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Required for 20S core proteasome assembly, essential for the degradation of meiotic proteins RAD51 and RPA1 at late prophase I and the progression of meiosis I during spermatogenesis. Localizes to the synaptonemal complex, a 'zipper'-like structure that holds homologous chromosome pairs in synapsis during meiotic prophase I.

Target Subcellular Location

Nucleus.

Target Protein Families

Peptidase T1A family

Target Synonyms

PSMA8; PSMA7L; Proteasome subunit alpha-type 8; EC 3.4.25.1; Proteasome alpha 4 subunit; Alpha4s; Proteasome subunit alpha-type 7-like

Target Background

Predicted to be involved in meiotic cell cycle and proteasomal protein catabolic process. Located in extracellular exosome and nucleus.