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| Cat.No | ACP21308 | Target Name | TGM5 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 2-720 | Protein Length | Full Length of Mature Protein |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O43548 |
|---|
Uniprot Id
O43548
Target Species
Human
Target Name
TGM5
Target Full Name
Protein-glutamine gamma-glutamyltransferase 5
Target Function
Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to the formation of the cornified cell envelope of keratinocytes.
Target Involvement
Peeling skin syndrome 2 (PSS2)
Target Subcellular Location
Cytoplasm. Note=Associated with intermediate filaments.
Target Protein Families
Transglutaminase superfamily, Transglutaminase family
Target Tissue Specificity
Expressed in foreskin keratinocytes.
Target Synonyms
Protein glutamine gamma glutamyltransferase 5; Protein-glutamine gamma-glutamyltransferase 5; PSS2; TG(X); TGase 5; TGase X; TGase-5; TGase5; TGASEX; Tgm5; TGM5_HUMAN; TGM6; TGMX; TGX; Transglutaminase X; Transglutaminase-5
Target Background
This gene encodes a member of the transglutaminase family. The encoded protein catalyzes formation of protein cross-links between glutamine and lysine residues, often resulting in stabilization of protein assemblies. This reaction is calcium dependent. Mutations in this gene have been associated with acral peeling skin syndrome.
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