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Dive into the world of cardiovascular research with our meticulously crafted Recombinant Human Protein-Lysine 6-Oxidase (LOX). LOX, also known as lysyl oxidase, is a copper-dependent enzyme involved in the cross-linking of collagen and elastin, contributing to the integrity and elasticity of blood vessels. Its association with various cardiovascular diseases makes it an important target for scientific investigations. Our Recombinant Human LOX protein is produced in an E.coli expression system, ensuring high-quality production. The protein encompasses the full length of the mature protein sequence (169-417aa) and features both N-terminal 10xHis-SUMO and C-terminal Myc tags, allowing for simplified purification and detection. With a purity of greater than 85% as determined by SDS-PAGE, our LOX protein guarantees consistent results across a variety of applications. Available in liquid and lyophilized powder forms, our Recombinant Human LOX protein is designed to meet the diverse needs of your cardiovascular research pursuits.
Dive into the world of cardiovascular research with our meticulously crafted Recombinant Human Protein-Lysine 6-Oxidase (LOX). LOX, also known as lysyl oxidase, is a copper-dependent enzyme involved in the cross-linking of collagen and elastin, contributing to the integrity and elasticity of blood vessels. Its association with various cardiovascular diseases makes it an important target for scientific investigations.
Our Recombinant Human LOX protein is produced in an E.coli expression system, ensuring high-quality production. The protein encompasses the full length of the mature protein sequence (169-417aa) and features both N-terminal 10xHis-SUMO and C-terminal Myc tags, allowing for simplified purification and detection. With a purity of greater than 85% as determined by SDS-PAGE, our LOX protein guarantees consistent results across a variety of applications. Available in liquid and lyophilized powder forms, our Recombinant Human LOX protein is designed to meet the diverse needs of your cardiovascular research pursuits.
| Cat.No | ACP02331 | Target Name | LOX |
|---|---|---|---|
| Target Synonyms | lox; LYOX; LYOX_HUMAN; Lysyl oxidase; MGC105112; Protein lysine 6 oxidase; Protein-lysine 6-oxidase | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 169-417aa |
| Mol Weight | 49.0 kDa | Protein Length | Full Length of Mature Protein |
| Purity | Greater than 85% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P28300 |
|---|
Uniprot Id
P28300
Target Species
Human
Target Name
LOX
Target Full Name
Protein-lysine 6-oxidase
Target Function
Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture.
Target Involvement
Aortic aneurysm, familial thoracic 10 (AAT10)
Target Subcellular Location
Secreted. Secreted, extracellular space.
Target Protein Families
Lysyl oxidase family
Target Tissue Specificity
Heart, placenta, skeletal muscle, kidney, lung and pancreas.
Target Research Area
Cardiovascular, Signal Transduction
Target Synonyms
lox; LYOX; LYOX_HUMAN; Lysyl oxidase; MGC105112; Protein lysine 6 oxidase; Protein-lysine 6-oxidase
Target Background
This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme. The copper-dependent amine oxidase activity of this enzyme functions in the crosslinking of collagens and elastin, while the propeptide may play a role in tumor suppression. In addition, defects in this gene have been linked with predisposition to thoracic aortic aneurysms and dissections.
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