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The pipeline for the recombinant Human MDM4 protein production in e.coli cells consists of the following consecutive steps: construction of the expression vector encoding the Human MDM4 protein (1-490aa), its transformation into e.coli cells, high-density cultivation and induction of the positive cells, cell lysis, and expression analysis. The protein features a N-terminal 6xHis tag fusion. The resulting recombinant Human MDM4 protein is purified from the cell lysate through affinity purification, and its purity is greater than 90% determined by the SDS-PAGE.
The pipeline for the recombinant Human MDM4 protein production in e.coli cells consists of the following consecutive steps: construction of the expression vector encoding the Human MDM4 protein (1-490aa), its transformation into e.coli cells, high-density cultivation and induction of the positive cells, cell lysis, and expression analysis. The protein features a N-terminal 6xHis tag fusion. The resulting recombinant Human MDM4 protein is purified from the cell lysate through affinity purification, and its purity is greater than 90% determined by the SDS-PAGE.
| Cat.No | ACP01823 | Target Name | MDM4 |
|---|---|---|---|
| Target Synonyms | Double minute 4 protein Mdm2-like p53-binding protein Protein Mdmx p53-binding protein Mdm4 | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 1-490aa |
| Mol Weight | 59.0 kDa | Protein Length | Full length |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O15151 |
|---|
Uniprot Id
O15151
Target Species
Human
Target Name
MDM4
Target Full Name
Protein Mdm4
Target Function
Along with MDM2, contributes to TP53 regulation. Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.
Target Subcellular Location
Nucleus.
Target Protein Families
MDM2/MDM4 family
Target Tissue Specificity
Expressed in all tissues tested with high levels in thymus.
Target Research Area
Cell Cycle
Target Synonyms
DKFZp781B1423; Double minute 4; Double minute 4 human homolog of p53 binding protein; Double minute 4 protein; HDMX; MDM 4; Mdm2 like p53 binding protein; Mdm2-like p53-binding protein; MDM4; Mdm4 p53 binding protein homolog mouse; Mdm4 protein; MDM4 related protein 1; Mdm4 transformed 3T3 cell double minute 4; Mdm4 transformed 3T3 cell double minute 4 p53 binding protein; Mdm4 transformed 3T3 cell double minute 4 p53 binding protein mouse; MDM4_HUMAN; Mdmx protein; MGC132766; Mouse double minute 4 homolog; Mouse double minute 4 human homolog of p53 binding protein; MRP 1; MRP1; p53 binding protein; p53 BINDING PROTEIN MDM4; p53-binding protein Mdm4; Protein Mdm4; Protein Mdmx
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