Recombinant Human Protein-methionine sulfoxide oxidase MICAL2 (MICAL2), Truncated

ACP02551

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Specifications

Cat.No	ACP02551	Target Name	MICAL2
Target Synonyms	MICAL2; KIAA0750; MICAL2PV1; MICAL2PV2; [F-actin]-monooxygenase MICAL2; EC 1.14.13.225; Molecule interacting with CasL protein 2; MICAL-2	Form	Liquid or Lyophilized powder
Expression System	Yeast	Expression Range	1-495aa
Mol Weight	58.5kDa	Protein Length	Partial
Purity	Greater than 90% as determined by SDS-PAGE.	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	O94851

Background Information

Uniprot Id

O94851
Target Species

Human
Target Name

MICAL2
Target Full Name

[F-actin]-monooxygenase MICAL2
Target Function

Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA.
Target Subcellular Location

Nucleus.
Target Protein Families

Mical family
Target Research Area

Cell Biology
Target Synonyms

MICAL2; KIAA0750; MICAL2PV1; MICAL2PV2; [F-actin]-monooxygenase MICAL2; EC 1.14.13.225; Molecule interacting with CasL protein 2; MICAL-2

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Recombinant Human Protein-methionine sulfoxide oxidase MICAL2 (MICAL2), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human Protein-methionine sulfoxide oxidase MICAL2 (MICAL2), Truncated Now

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