Recombinant Human Protein-methionine sulfoxide oxidase MICAL3 (MICAL3), Truncated

Uniprot Id

Q7RTP6

Target Species

Human

Target Name

MICAL3

Target Full Name

[F-actin]-monooxygenase MICAL3

Target Function

Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission

Target Subcellular Location

Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Nucleus. Midbody. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, cilium basal body.

Target Protein Families

Mical family

Target Tissue Specificity

Ubiquitous.

Target Synonyms

MICAL3; KIAA0819; KIAA1364; [F-actin]-monooxygenase MICAL3; EC 1.14.13.225; Molecule interacting with CasL protein 3; MICAL-3