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| Cat.No | ACP21848 | Target Name | TTLL8 |
|---|---|---|---|
| Target Synonyms | TTLL8; Protein monoglycylase TTLL8; EC 6.3.2.-; Tubulin--tyrosine ligase-like protein 8 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | A6PVC2 |
|---|
Uniprot Id
A6PVC2
Target Species
Human
Target Name
TTLL8
Target Full Name
Protein monoglycylase TTLL8
Target Function
Monoglycylase which modifies both tubulin and non-tubulin proteins, adding a single glycine to the gamma-carboxyl groups of specific glutamate residues to generate monoglycine side chains within the C-terminal tail of target proteins. Not involved in elongation step of the polyglycylation reaction. Preferentially monoglycylates alpha-tubulin over beta-tubulin. Together with TTLL3, mediates microtubule glycylation of primary and motile cilia, which is essential for their stability and maintenance. Together with TTLL3, glycylates sperm flagella which regulates axonemal dynein motor activity, thereby controlling flagellar beat, directional sperm swimming and male fertility. Monoglycylates non-tubulin proteins such as ANP32A, ANP32B, SET, NCL and NAP1.
Target Subcellular Location
Cytoplasm, cytoskeleton. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme.
Target Synonyms
TTLL8; Protein monoglycylase TTLL8; EC 6.3.2.-; Tubulin--tyrosine ligase-like protein 8
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