Recombinant Human Protein pelota homolog (PELO)

Uniprot Id

Q9BRX2

Target Species

Human

Target Name

PELO

Target Full Name

Protein pelota homolog

Target Function

Cotranslational quality control factor involved in the No-Go Decay (NGD) pathway. In the presence of ABCE1 and HBS1L, is required for 48S complex formation from 80S ribosomes and dissociation of vacant 80S ribosomes. Together with HBS1L and in presence of ABCE1, recognizes stalled ribosomes and promotes dissociation of elongation complexes assembled on non-stop mRNAs; this triggers endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and to degrade damaged mRNAs as part of the No-Go Decay (NGD) pathway. As part of the PINK1-regulated signaling, upon mitochondrial damage is recruited to the ribosome/mRNA-ribonucleoprotein complex associated to mitochondrial outer membrane thereby enabling the recruitment of autophagy receptors and induction of mitophagy.

Target Subcellular Location

Nucleus. Cytoplasm.

Target Protein Families

Eukaryotic release factor 1 family, Pelota subfamily

Target Tissue Specificity

Ubiquitously expressed.

Target Synonyms

CGI 17; CGI17; pelo; PELO_HUMAN; pelota (Drosophila) homolog ; pelota homolog ; PRO1770; Protein pelota homolog

Target Background

This gene encodes a protein which contains a conserved nuclear localization signal. The encoded protein may have a role in spermatogenesis, cell cycle control, and in meiotic cell division.