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Enhance your immunological research with the Recombinant Human Protein S100-A12 (S100A12), a protein with crucial roles in inflammation, immune response, and cellular signaling pathways. S100A12 has been linked to various immune-mediated diseases, making it a potential target for diagnostic and therapeutic applications. Our Recombinant Human S100A12 protein is produced in a dependable E.coli expression system, ensuring a high-quality and consistent source for your research needs. The full-length mature protein sequence (2-92aa) is N-terminal GST-tagged to facilitate affinity purification while maintaining its native conformation and activity. With a purity greater than 90% as determined by SDS-PAGE, our S100A12 protein guarantees reliable and reproducible results in a variety of experimental setups. Choose between liquid and lyophilized powder forms to best suit your research demands, and harness the power of our premium-quality Recombinant Human S100A12 protein in your immunology research.
Enhance your immunological research with the Recombinant Human Protein S100-A12 (S100A12), a protein with crucial roles in inflammation, immune response, and cellular signaling pathways. S100A12 has been linked to various immune-mediated diseases, making it a potential target for diagnostic and therapeutic applications.
Our Recombinant Human S100A12 protein is produced in a dependable E.coli expression system, ensuring a high-quality and consistent source for your research needs. The full-length mature protein sequence (2-92aa) is N-terminal GST-tagged to facilitate affinity purification while maintaining its native conformation and activity. With a purity greater than 90% as determined by SDS-PAGE, our S100A12 protein guarantees reliable and reproducible results in a variety of experimental setups. Choose between liquid and lyophilized powder forms to best suit your research demands, and harness the power of our premium-quality Recombinant Human S100A12 protein in your immunology research.
| Cat.No | ACP03676 | Target Name | S100A12 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 2-92aa | Mol Weight | 37.4kDa |
| Protein Length | Full Length of?Mature?Protein | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P80511 |
|---|
Uniprot Id
P80511
Target Species
Human
Target Name
S100A12
Target Full Name
Protein S100-A12
Target Function
S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn(2+) from their active sites. Possesses filariacidal and filariastatic activity. Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus.
Target Subcellular Location
Secreted. Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein. Note=Predominantly localized in the cytoplasm. Upon elevation of the intracellular calcium level, translocated from the cytoplasm to the cytoskeleton and the cell membrane. Upon neutrophil activation is secreted via a microtubule-mediated, alternative pathway.
Target Protein Families
S-100 family
Target Tissue Specificity
Predominantly expressed by neutrophils, monocytes and activated macrophages. Expressed by eosinophils and macrophages in asthmatic airways in regions where mast cells accumulate. Found in high concentrations in the serum of patients suffering from various
Target Research Area
Immunology
Target Synonyms
CAAF1; CAGC; Calcitermin; Calcium-binding protein in amniotic fluid 1; Calgranulin C; Calgranulin-C; Calgranulin-related protein; CGRP; EN RAGE; EN-RAGE; ENRAGE; Extracellular newly identified RAGE-binding protein; migration inhibitory factor-related protein 6; MRP6; Neutrophil S100 protein; p6; Protein S100 A12; S100 calcium binding protein A12; S100 calcium-binding protein A12 (calgranulin C); S100 calcium-binding protein A12; S100A12; S10AC_HUMAN
Target Background
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities. The protein includes an antimicrobial peptide which has antibacterial activity.
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