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| Cat.No | ACP16376 | Target Name | PYHIN1 |
|---|---|---|---|
| Target Synonyms | IFIX_HUMAN; Interferon-inducible protein X; Pyhin1; Pyrin and HIN domain-containing protein 1 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-492 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q6K0P9 |
|---|
Uniprot Id
Q6K0P9
Target Species
Human
Target Name
PYHIN1
Target Full Name
Pyrin and HIN domain-containing protein 1
Target Function
Major mediator of the tumor suppressor activity of IFN in breast cancer cells. Promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization. Promotes ubiquitination and subsequent degradation of HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells.
Target Subcellular Location
[Isoform 1]: Nucleus, nucleoplasm.; [Isoform 3]: Nucleus, nucleoplasm.; [Isoform 5]: Nucleus. Nucleus speckle.
Target Protein Families
HIN-200 family
Target Tissue Specificity
Expressed in spleen, lymph node and peripheral blood leukocytes, and at lower levels in thymus, bone marrow and fetal liver. Down-regulated in breast tumors.
Target Synonyms
IFIX_HUMAN; Interferon-inducible protein X; Pyhin1; Pyrin and HIN domain-containing protein 1
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