Recombinant Human Rab GDP dissociation inhibitor beta (GDI2)

Uniprot Id

P50395

Target Species

Human

Target Name

GDI2

Target Full Name

Rab GDP dissociation inhibitor beta

Target Function

Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.

Target Subcellular Location

Cytoplasm. Membrane; Peripheral membrane protein.

Target Protein Families

Rab GDI family

Target Tissue Specificity

Ubiquitous.

Target Research Area

Signal Transduction

Target Synonyms

GDI-2; GDI2; GDIB_HUMAN; GDP dissociation inhibitor 2; Guanosine diphosphate dissociation inhibitor 2; Rab GDI beta; Rab GDP dissociation inhibitor beta; RABGDIB

Target Background

GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI2 is ubiquitously expressed. The GDI2 gene contains many repetitive elements indicating that it may be prone to inversion/deletion rearrangements. Alternative splicing results in multiple transcript variants encoding distinct isoforms.