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| Cat.No | ACP16721 | Target Name | RABGAP1L |
|---|---|---|---|
| Target Synonyms | RABGAP1L; HHL; KIAA0471; Rab GTPase-activating protein 1-like | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q5R372 |
|---|
Uniprot Id
Q5R372
Target Species
Human
Target Name
RABGAP1L
Target Full Name
Rab GTPase-activating protein 1-like
Target Function
GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP. Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration.
Target Involvement
Leukemia, acute myelogenous (AML)
Target Subcellular Location
Cytoplasmic vesicle. Early endosome. Golgi apparatus.
Target Synonyms
RABGAP1L; HHL; KIAA0471; Rab GTPase-activating protein 1-like
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