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| Cat.No | ACP15081 | Target Name | RASEF |
|---|---|---|---|
| Target Synonyms | RASEF; RAB45; Ras and EF-hand domain-containing protein; Ras-related protein Rab-45 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-740 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8IZ41 |
|---|
Uniprot Id
Q8IZ41
Target Species
Human
Target Name
RASEF
Target Full Name
Ras and EF-hand domain-containing protein
Target Function
Binds predominantly GDP, and also GTP. Acts as a dynein adapter protein that activates dynein-mediated transport and dynein-dynactin motility on microtubules.
Target Subcellular Location
Cytoplasm, perinuclear region.
Target Protein Families
Small GTPase superfamily, Rab family
Target Tissue Specificity
Down-regulated in cutaneous melanoma cells but not in breast cancer cells.
Target Synonyms
RASEF; RAB45; Ras and EF-hand domain-containing protein; Ras-related protein Rab-45
Target Background
This gene is a member of the Rab family of GTPases that are involved in regulation of membrane traffic. The encoded protein contains an N-terminal EF-hand domain, a coiled-coil motif and a C-terminal Rab domain. A potential role as tumor suppressor has been indicated for this gene.
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