Recombinant Human Ras association domain-containing protein 5 (RASSF5)

Uniprot Id

Q8WWW0

Target Species

Human

Target Name

RASSF5

Target Full Name

Ras association domain-containing protein 5

Target Function

Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis.

Target Subcellular Location

Cytoplasm. Cytoplasm, cytoskeleton. Note=Isoform 2 is mainly located in the perinuclear region of unstimulated primary T-cells. Upon stimulation translocates to the leading edge and colocalizes with ITGAL/LFA-1 in the peripheral zone of the immunological synapse. Isoform 2 is localized to growing microtubules in vascular endothelial cells and is dissociated from microtubules by activated RAP1A.

Target Tissue Specificity

Widely expressed. Frequently down-regulated in lung tumor cell lines and primary lung tumors.

Target Research Area

Cell Biology

Target Synonyms

Maxp 1; MAXP1; MGC10823; MGC17344; New ras effector 1; NORE 1; NORE1; NORE1A; NORE1B; Novel Ras effector 1; RAP1 Binding Protein; RAPL; Ras association (RalGDS/AF 6) domain family 5; Ras association (RalGDS/AF 6) domain family member 5; Ras association domain containing family protein 5; Ras association domain-containing protein 5; Ras effector like protein; RASF5_HUMAN; RASSF 3; RASSF 5; RASSF3; RASSF5; Regulator for cell adhesion and polarization enriched in lymphoid tissue; Regulator for cell adhesion and polarization enriched in lymphoid tissues; Tumor suppressor RASSF3

Target Background

This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene.