Recombinant Human Ras-related GTP-binding protein A (RRAGA)

Uniprot Id

Q7L523

Target Species

Human

Target Name

RRAGA

Target Full Name

Ras-related GTP-binding protein A

Target Function

Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death.; (Microbial infection) May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death.

Target Subcellular Location

Cytoplasm. Nucleus. Lysosome.

Target Protein Families

GTR/RAG GTP-binding protein family

Target Tissue Specificity

Ubiquitously expressed with highest levels of expression in skeletal muscle, heart, and brain.

Target Research Area

Apoptosis

Target Synonyms

Adenovirus E3 14.7 kDa-interacting protein 1; FIP-1; Rag A; RagA; Ras-related GTP-binding protein A; RRAGA; RRAGA_HUMAN

Target Background

Enables several functions, including GTP binding activity; protein dimerization activity; and ubiquitin protein ligase binding activity. Involved in several processes, including cellular response to amino acid starvation; negative regulation of autophagy; and positive regulation of TORC1 signaling. Located in lysosome and nucleus. Colocalizes with GATOR1 complex.