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| Cat.No | ACP03409 | Target Name | RGS7 |
|---|---|---|---|
| Target Synonyms | RGS7; Regulator of G-protein signaling 7; RGS7 | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 1-487aa |
| Mol Weight | 60.7kDa | Protein Length | Full Length of Isoform 5 |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P49802 |
|---|
Uniprot Id
P49802
Target Species
Human
Target Name
RGS7
Target Full Name
Regulator of G-protein signaling 7
Target Function
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS7/GNB5 dimer enhances GNAO1 GTPase activity. May play a role in synaptic vesicle exocytosis. Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling.
Target Subcellular Location
Cytoplasm, cytosol. Cytoplasm. Cell membrane. Membrane; Peripheral membrane protein; Cytoplasmic side.
Target Research Area
Signal Transduction
Target Synonyms
RGS7; Regulator of G-protein signaling 7; RGS7
Target Background
Enables G-protein beta-subunit binding activity and GTPase activator activity. Involved in positive regulation of GTPase activity. Located in cytosol.
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