Recombinant Human Repulsive guidance molecule A (RGMA)

Uniprot Id

Q96B86

Target Species

Human

Target Name

RGMA

Target Full Name

Repulsive guidance molecule A

Target Function

Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.

Target Subcellular Location

Cell membrane; Lipid-anchor, GPI-anchor.

Target Protein Families

Repulsive guidance molecule (RGM) family

Target Research Area

Neuroscience

Target Synonyms

Repulsive guidance molecule A; RGM; RGM domain family member A; RGMA; RGMA_HUMAN

Target Background

This gene encodes a member of the repulsive guidance molecule family. The encoded protein is a glycosylphosphatidylinositol-anchored glycoprotein that functions as an axon guidance protein in the developing and adult central nervous system. This protein may also function as a tumor suppressor in some cancers. Alternate splicing results in multiple transcript variants.