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| Cat.No | ACP08399 | Target Name | RTN1 |
|---|---|---|---|
| Target Synonyms | RTN1; NSP; Reticulon-1; Neuroendocrine-specific protein | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q16799 |
|---|
Uniprot Id
Q16799
Target Species
Human
Target Name
RTN1
Target Full Name
Reticulon-1
Target Function
Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity.
Target Subcellular Location
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Target Tissue Specificity
Expressed in neural and neuroendocrine tissues and cell cultures derived therefrom. Expression of isoform RTN1-C is strongly correlated with neuronal differentiation.
Target Synonyms
RTN1; NSP; Reticulon-1; Neuroendocrine-specific protein
Target Background
This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. This gene is considered to be a specific marker for neurological diseases and cancer, and is a potential molecular target for therapy. Alternative splicing results in multiple transcript variants.
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