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Recombinant Human Retinol dehydrogenase 12 (RDH12)

ACP04332

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Specifications

Cat.No	ACP04332	Target Name	RDH12
Form	Liquid or Lyophilized powder	Expression System	E.coli
Expression Range	1-316aa	Mol Weight	51.1kDa
Protein Length	Full length	Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q96NR8

Background Information

Uniprot Id

Q96NR8
Target Species

Human
Target Name

RDH12
Target Full Name

Retinol dehydrogenase 12
Target Function

Retinoids dehydrogenase/reductase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinal. Shows very weak activity towards 13-cis-retinol. Also exhibits activity, albeit with lower affinity than for retinaldehydes, towards lipid peroxidation products (C9 aldehydes) such as 4-hydroxynonenal and trans-2-nonenal. May play an important function in photoreceptor cells to detoxify 4-hydroxynonenal and potentially other toxic aldehyde products resulting from lipid peroxidation. Has no dehydrogenase activity towards steroids.
Target Involvement

Leber congenital amaurosis 13 (LCA13); Retinitis pigmentosa 53 (RP53)
Target Subcellular Location

Endoplasmic reticulum membrane.
Target Protein Families

Short-chain dehydrogenases/reductases (SDR) family
Target Tissue Specificity

Widely expressed, mostly in retina, kidney, brain, skeletal muscle, pancreas and stomach.
Target Research Area

Metabolism
Target Synonyms

All trans and 9 cis retinol dehydrogenase; All-trans and 9-cis retinol dehydrogenase; LCA 3; LCA13; LCA3; RDH 12; RDH12; RDH12_HUMAN; Retinol dehydrogenase 12 (all trans/9 cis/11 cis); Retinol dehydrogenase 12 all trans and 9 cis; Retinol dehydrogenase 12; RP53; SDR7C2; Short chain dehydrogenase/reductase family 7C member 2

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Recombinant Human Retinol dehydrogenase 12 (RDH12)

Specifications

Immunogen Information

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