Recombinant Human Rho GTPase-activating protein 4 (ARHGAP4), Truncated

Uniprot Id

P98171

Target Species

Human

Target Name

ARHGAP4

Target Full Name

Rho GTPase-activating protein 4

Target Function

Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells.

Target Subcellular Location

Cytoplasm. Note=Just below the plasma membrane.

Target Tissue Specificity

Predominantly in hematopoietic cells (spleen, thymus and leukocytes); low levels in placenta, lung and various fetal tissues.

Target Synonyms

ARHGAP4; KIAA0131; RGC1; RHOGAP4; Rho GTPase-activating protein 4; Rho-GAP hematopoietic protein C1; Rho-type GTPase-activating protein 4; p115

Target Background

This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins belonging to the RAS superfamily. The protein encoded by the orthologous gene in rat is localized to the Golgi complex and can redistribute to microtubules. The rat protein stimulates the activity of some Rho GTPases in vitro. Genomic deletions of this gene and a neighboring gene have been found in patients with nephrogenic diabetes insipidus. Multiple transcript variants encoding different isoforms have been found for this gene.