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Recombinant Human Riboflavin kinase (RFK)

ACP14441

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Specifications

Cat.No	ACP14441	Target Name	RFK
Target Synonyms	0610038L10Rik; AF031381; ATP:riboflavin 5' phosphotransferase; ATP:riboflavin 5''-phosphotransferase; Flavokinase; FLJ11149; KOI 4; Rfk; Riboflavin kinase; RIFK; RIFK_HUMAN; RP11-422N19.2	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	1-155
Protein Length	Full length protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q969G6

Background Information

Uniprot Id

Q969G6
Target Species

Human
Target Name

RFK
Target Full Name

Riboflavin kinase
Target Function

Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. TNF-activation of RFK may enhance the incorporation of FAD in NADPH oxidase, a critical step for the assembly and activation of NADPH oxidase.
Target Subcellular Location

Cytoplasm.
Target Tissue Specificity

Detected in brain, placenta and urinary bladder.
Target Synonyms

0610038L10Rik; AF031381; ATP:riboflavin 5' phosphotransferase; ATP:riboflavin 5''-phosphotransferase; Flavokinase; FLJ11149; KOI 4; Rfk; Riboflavin kinase; RIFK; RIFK_HUMAN; RP11-422N19.2
Target Background

Riboflavin kinase (RFK; EC 2.7.1.26) is an essential enzyme that catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN), an obligatory step in vitamin B2 utilization and flavin cofactor synthesis (Karthikeyan et al., 2003 [PubMed 12623014]).

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Recombinant Human Riboflavin kinase (RFK)

Specifications

Immunogen Information

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