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Amino acids 1-389 constitute the expression domain of recombinant Human RRM2. The calculated molecular weight for this RRM2 protein is 60.9 kDa. The RRM2 protein was expressed in e.coli. The RRM2 coding gene included the N-terminal 6xHis-SUMO tag, which simplifies the detection and purification processes of the recombinant RRM2 protein in following stages of expression and purification.The human ribonucleoside-diphosphate reductase subunit M2 (RRM2) is a critical enzyme involved in DNA synthesis and repair. As the small subunit of ribonucleotide reductase, RRM2 plays a key role in catalyzing the conversion of ribonucleotides to deoxyribonucleotides, which are essential building blocks for DNA replication. This process is crucial for cell proliferation and the maintenance of genomic integrity. RRM2 is tightly regulated throughout the cell cycle, ensuring the availability of deoxyribonucleotides during the DNA synthesis phases. Dysregulation of RRM2 has been implicated in various cancers, making it a potential target for anticancer therapies. Research on RRM2 spans areas such as cancer biology, cell cycle regulation, and nucleotide metabolism, contributing to the understanding of its functions and its potential as a therapeutic target in cancer treatment.
Amino acids 1-389 constitute the expression domain of recombinant Human RRM2. The calculated molecular weight for this RRM2 protein is 60.9 kDa. The RRM2 protein was expressed in e.coli. The RRM2 coding gene included the N-terminal 6xHis-SUMO tag, which simplifies the detection and purification processes of the recombinant RRM2 protein in following stages of expression and purification.The human ribonucleoside-diphosphate reductase subunit M2 (RRM2) is a critical enzyme involved in DNA synthesis and repair. As the small subunit of ribonucleotide reductase, RRM2 plays a key role in catalyzing the conversion of ribonucleotides to deoxyribonucleotides, which are essential building blocks for DNA replication. This process is crucial for cell proliferation and the maintenance of genomic integrity. RRM2 is tightly regulated throughout the cell cycle, ensuring the availability of deoxyribonucleotides during the DNA synthesis phases. Dysregulation of RRM2 has been implicated in various cancers, making it a potential target for anticancer therapies. Research on RRM2 spans areas such as cancer biology, cell cycle regulation, and nucleotide metabolism, contributing to the understanding of its functions and its potential as a therapeutic target in cancer treatment.
| Cat.No | ACP04048 | Target Name | RRM2 |
|---|---|---|---|
| Target Synonyms | R2 subunit; RIR2_HUMAN; RR2; RR2M; RRM2 | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 1-389a |
| Mol Weight | 60.9kDa | Protein Length | Full length |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P31350 |
|---|
Uniprot Id
P31350
Target Species
Human
Target Name
RRM2
Target Full Name
Ribonucleoside-diphosphate reductase subunit M2
Target Function
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.
Target Subcellular Location
Cytoplasm. Nucleus.
Target Protein Families
Ribonucleoside diphosphate reductase small chain family
Target Research Area
Transcription
Target Synonyms
cb111; chunp6884; etID309896.20; R2; reductase M2 polypeptide variant 1; reductase M2 polypeptide variant 2; reductase M2 polypeptide variant 3a; reductase M2 polypeptide variant 3b; reductase M2 polypeptide variant 3c; reductase M2 polypeptide variant 3d; Ribonucleoside-diphosphate reductase subunit M2; Ribonucleotide reductase M2; Ribonucleotide reductase M2 polypeptide; Ribonucleotide reductase M2 subunit; ribonucleotide reductase protein r2 class I; Ribonucleotide reductase regulatory subunit M2; Ribonucleotide reductase small chain; Ribonucleotide reductase small subunit; Ribonucleotide reductase, R2 subunit; RIR2_HUMAN; RR2; RR2M; RRM2
Target Background
This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X.
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