Recombinant Human RING finger protein 145 (RNF145), Truncated

Uniprot Id

Q96MT1

Target Species

Human

Target Name

RNF145

Target Full Name

RING finger protein 145

Target Function

E3 ubiquitin ligase that catalyzes the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. In response to bacterial infection, negatively regulates the phagocyte oxidative burst by controlling the turnover of the NADPH oxidase complex subunits. Promotes monoubiquitination of CYBA and 'Lys-48'-linked polyubiquitination and degradation of CYBB NADPH oxidase catalytic subunits, both essential for the generation of antimicrobial reactive oxygen species. Involved in the maintenance of cholesterol homeostasis. In response to high sterol concentrations ubiquitinates HMGCR, a rate-limiting enzyme in cholesterol biosynthesis, and targets it for degradation. The interaction with INSIG1 is required for this function. In addition, triggers ubiquitination of SCAP, likely inhibiting its transport to the Golgi apparatus and the subsequent processing/maturation of SREBPF2, ultimately downregulating cholesterol biosynthesis

Target Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Target Synonyms

FLJ31951; RING finger protein 145; RN145_HUMAN; rnf145