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| Cat.No | ACP19300 | Target Name | RNF169 |
|---|---|---|---|
| Target Synonyms | E3 ubiquitin-protein ligase RNF169; KIAA1991; RING finger protein 169; RN169_HUMAN; RNF169 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-708 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8NCN4 |
|---|
Uniprot Id
Q8NCN4
Target Species
Human
Target Name
RNF169
Target Full Name
E3 ubiquitin-protein ligase RNF169
Target Function
Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage. Recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168 and competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby acting as a negative regulator of DSBs repair. E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair.
Target Subcellular Location
Nucleus, nucleoplasm. Note=Localizes to sites of double-strand breaks (DSBs) following DNA damage. Recruited to DSBs via recognition of RNF168-dependent ubiquitin products.
Target Protein Families
RNF169 family
Target Synonyms
E3 ubiquitin-protein ligase RNF169; KIAA1991; RING finger protein 169; RN169_HUMAN; RNF169
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