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| Cat.No | ACP08493 | Target Name | RNF186 |
|---|---|---|---|
| Target Synonyms | RNF186; E3 ubiquitin-protein ligase RNF186; RING finger protein 186 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9NXI6 |
|---|
Uniprot Id
Q9NXI6
Target Species
Human
Target Name
RNF186
Target Full Name
E3 ubiquitin-protein ligase RNF186
Target Function
E3 ubiquitin protein ligase that is part of an apoptotic signaling pathway activated by endoplasmic reticulum stress. In that process, stimulates the expression of proteins specific of the unfolded protein response (UPR), ubiquitinates BNIP1 and regulates its localization to the mitochondrion and induces calcium release from the endoplasmic reticulum that ultimately leads to cell apoptosis.
Target Subcellular Location
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Target Synonyms
RNF186; E3 ubiquitin-protein ligase RNF186; RING finger protein 186
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