Recombinant Human Secreted frizzled-related protein 3 (FRZB)

Uniprot Id

Q92765

Target Species

Human

Target Name

FRZB

Target Full Name

Secreted frizzled-related protein 3

Target Function

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.

Target Involvement

Osteoarthritis 1 (OS1)

Target Subcellular Location

Secreted.

Target Protein Families

Secreted frizzled-related protein (sFRP) family

Target Tissue Specificity

Expressed primarily in the cartilaginous cores of the long bone during embryonic and fetal development and in the appendicular skeleton (6-13 weeks). At 13 weeks of gestation, transcripts were present in early chondroblasts of the tarsal bones of the foot

Target Synonyms

FRZB; FIZ; FRE; FRP; FRZB1; SFRP3; Secreted frizzled-related protein 3; sFRP-3; Frezzled; Fritz; Frizzled-related protein 1; FrzB-1

Target Background

The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility.