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Explore the intricate world of cardiovascular research with our Recombinant Human SLURP1 protein. Secreted Ly-6/uPAR-related protein 1 (SLURP-1) is a member of the Ly-6/uPAR family of proteins and has been implicated in various biological processes, including the regulation of keratinocyte proliferation and differentiation, as well as having potential implications in inflammatory and autoimmune diseases. Our Recombinant Human SLURP1 protein is expressed in E.coli, ensuring a high-quality full-length mature protein (23-103aa) that retains its native structure and functionality. The N-terminal 6xHis-tag enables efficient protein purification and easy detection. With a purity greater than 90% as determined by SDS-PAGE, our Recombinant Human SLURP1 protein delivers reliable and consistent results for your cardiovascular research endeavors. Available in both liquid and lyophilized powder forms, our Recombinant Human SLURP1 protein is a valuable asset for investigating the complex mechanisms underlying cardiovascular health and disease.
Explore the intricate world of cardiovascular research with our Recombinant Human SLURP1 protein. Secreted Ly-6/uPAR-related protein 1 (SLURP-1) is a member of the Ly-6/uPAR family of proteins and has been implicated in various biological processes, including the regulation of keratinocyte proliferation and differentiation, as well as having potential implications in inflammatory and autoimmune diseases.
Our Recombinant Human SLURP1 protein is expressed in E.coli, ensuring a high-quality full-length mature protein (23-103aa) that retains its native structure and functionality. The N-terminal 6xHis-tag enables efficient protein purification and easy detection. With a purity greater than 90% as determined by SDS-PAGE, our Recombinant Human SLURP1 protein delivers reliable and consistent results for your cardiovascular research endeavors. Available in both liquid and lyophilized powder forms, our Recombinant Human SLURP1 protein is a valuable asset for investigating the complex mechanisms underlying cardiovascular health and disease.
| Cat.No | ACP03765 | Target Name | SLURP1 |
|---|---|---|---|
| Target Synonyms | SLURP1; ARS; Secreted Ly-6/uPAR-related protein 1; SLURP-1; ARS component B; ARS(component B)-81/S; Anti-neoplastic urinary protein; ANUP | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 23-103aa |
| Mol Weight | 12.9kDa | Protein Length | Full Length of Mature Protein |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P55000 |
|---|
Uniprot Id
P55000
Target Species
Human
Target Name
SLURP1
Target Full Name
Secreted Ly-6/uPAR-related protein 1
Target Function
Has an antitumor activity. Was found to be a marker of late differentiation of the skin. Implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin. In vitro down-regulates keratinocyte proliferation; the function may involve the proposed role as modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-7-dependent nAChR currents in an allosteric manner. In T cells may be involved in regulation of intracellular Ca(2+) signaling. Seems to have an immunomodulatory function in the cornea. The function may implicate a possible role as a scavenger receptor for PLAU thereby blocking PLAU-dependent functions of PLAUR such as in cell migration and proliferation.
Target Involvement
Mal de Meleda (MDM)
Target Subcellular Location
Secreted.
Target Tissue Specificity
Granulocytes. Expressed in skin. Predominantly expressed in the granular layer of skin, notably the acrosyringium. Identified in several biological fluids such as sweat, saliva, tears, plasma and urine.
Target Research Area
Cardiovascular
Target Synonyms
SLURP1; ARS; Secreted Ly-6/uPAR-related protein 1; SLURP-1; ARS component B; ARS(component B)-81/S; Anti-neoplastic urinary protein; ANUP
Target Background
The protein encoded by this gene is a member of the Ly6/uPAR family but lacks a GPI-anchoring signal sequence. It is thought that this secreted protein contains antitumor activity. Mutations in this gene have been associated with Mal de Meleda, a rare autosomal recessive skin disorder. This gene maps to the same chromosomal region as several members of the Ly6/uPAR family of glycoprotein receptors.
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