Recombinant Human Selenoprotein T (SELT)

Uniprot Id

P62341

Target Species

Human

Target Name

SELENOT

Target Full Name

Thioredoxin reductase-like selenoprotein T

Target Function

Selenoprotein with thioredoxin reductase-like oxidoreductase activity. Protects dopaminergic neurons against oxidative stress ans cell death. Involved in ADCYAP1/PACAP-induced calcium mobilization and neuroendocrine secretion. Plays a role in fibroblast anchorage and redox regulation. In gastric smooth muscle, modulates the contraction processes through the regulation of calcium release and MYLK activation. In pancreatic islets, involved in the control of glucose homeostasis, contributes to prolonged ADCYAP1/PACAP-induced insulin secretion.

Target Involvement

mRNA levels are increased more than 200-folds in the caudate putamen from Parkinson disease (PD) patients compared to control subjects. In conditional brain knockout mice, treatment with PD-inducing neurotoxins provoke rapid and severe parkinsonian-like motor defects.

Target Subcellular Location

Endoplasmic reticulum membrane; Single-pass membrane protein.

Target Protein Families

SelWTH family, Selenoprotein T subfamily

Target Tissue Specificity

Ubiquitous. Highly expressed in the endocrine pancreas.

Target Synonyms

Selenoprotein T; SelT; SELT_HUMAN