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| Cat.No | ACP18500 | Target Name | SEMA5A |
|---|---|---|---|
| Target Synonyms | SEMA5A; SEMAF; Semaphorin-5A; Semaphorin-F; Sema F | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q13591 |
|---|
Uniprot Id
Q13591
Target Species
Human
Target Name
SEMA5A
Target Full Name
Semaphorin-5A
Target Function
Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis.
Target Subcellular Location
Membrane; Single-pass type I membrane protein.
Target Protein Families
Semaphorin family
Target Synonyms
SEMA5A; SEMAF; Semaphorin-5A; Semaphorin-F; Sema F
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