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| Cat.No | ACP03592 | Target Name | SPR |
|---|---|---|---|
| Target Synonyms | 8 dihydrobiopterin:NADP+ oxidoreductase); Sepiapterin reductase; Short chain dehydrogenase/reductase family 38C, member 1; SPR; SPRE_HUMAN, OTTHUMP00000160199; SDR38C1; Sepiapterin reductase (7 | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 1-261aa |
| Mol Weight | 32.0 kDa | Protein Length | Full length |
| Purity | Greater than 85% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P35270 |
|---|
Uniprot Id
P35270
Target Species
Human
Target Name
SPR
Target Full Name
Sepiapterin reductase
Target Function
Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.
Target Involvement
Dystonia, DOPA-responsive, due to sepiapterin reductase deficiency (DRDSPRD)
Target Subcellular Location
Cytoplasm.
Target Protein Families
Sepiapterin reductase family
Target Research Area
Signal Transduction
Target Synonyms
OTTHUMP00000160199; SDR38C1; Sepiapterin reductase (7,8 dihydrobiopterin:NADP+ oxidoreductase); Sepiapterin reductase; Short chain dehydrogenase/reductase family 38C, member 1; SPR; SPRE_HUMAN
Target Background
This gene encodes an aldo-keto reductase that catalyzes the NADPH-dependent reduction of pteridine derivatives and is important in the biosynthesis of tetrahydrobiopterin (BH4). Mutations in this gene result in DOPA-responsive dystonia due to sepiaterin reductase deficiency. A pseudogene has been identified on chromosome 1.
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