Recombinant Human Serine/threonine-protein kinase 25 (STK25)

Uniprot Id

O00506

Target Species

Human

Target Name

STK25

Target Full Name

Serine/threonine-protein kinase 25

Target Function

Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration.

Target Subcellular Location

Cytoplasm. Golgi apparatus. Note=Localizes to the Golgi apparatus.

Target Protein Families

Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily

Target Tissue Specificity

Ubiquitously expressed. Highest levels are found in testis, large intestine, brain and stomach followed by heart and lung.

Target Research Area

Signal Transduction

Target Synonyms

C86992; Serine/threonine kinase 25; Serine/threonine kinase 25 (STE20 homolog, yeast); Serine/threonine kinase 25 (STE20 homolog, yeast), isoform CRA_a; Serine/threonine kinase 25 (yeast); Serine/threonine protein kinase 25; Serine/threonine-protein kinase 25; SOK 1; SOK-1; SOK1; Ste20 like kinase; Ste20 yeast homolog; Ste20-like; STE20-like kinase; Ste20/oxidant stress response kinase 1; Sterile 20 (oxidant stress response kinase 1); Sterile 20/oxidant stress-response kinase 1; STK25; STK25_HUMAN; Yeast Sps1/Ste20 related kinase 1; YSK 1; YSK1

Target Background

This gene encodes a member of the germinal centre kinase III (GCK III) subfamily of the sterile 20 superfamily of kinases. The encoded enzyme plays a role in serine-threonine liver kinase B1 (LKB1) signaling pathway to regulate neuronal polarization and morphology of the Golgi apparatus. The protein is translocated from the Golgi apparatus to the nucleus in response to chemical anoxia and plays a role in regulation of cell death. A pseudogene associated with this gene is located on chromosome 18. Multiple alternatively spliced transcript variants have been observed for this gene.