Recombinant Human Serine/threonine-protein kinase MST4 (MST4)

Uniprot Id

Q9P289

Target Species

Human

Target Name

STK26

Target Full Name

Serine/threonine-protein kinase 26

Target Function

Mediator of cell growth. Modulates apoptosis. In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation.

Target Subcellular Location

Cytoplasm. Golgi apparatus.

Target Protein Families

Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily

Target Synonyms

2610018G03Rik; EC 2.7.11.1; Mammalian Ste20 like protein kinase 4; Mammalian STE20-like protein kinase 4; Mammalian sterile 20 like 4; MASK; MST 4; MST-4; MST3 and SOK1 related kinase; Mst3 and SOK1-related kinase; Mst4; MST4_HUMAN; RGD1563568; RP23-245F8.1; RP6 213H19.1; Serine/threonine protein kinase 26; Serine/threonine protein kinase MASK; Serine/threonine protein kinase MST 4; Serine/threonine protein kinase MST4; Serine/threonine-protein kinase MASK; Serine/threonine-protein kinase MST4; STE20 like kinase MST 4; STE20 like kinase MST4; STE20-like kinase MST4; STK26

Target Background

The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.