Recombinant Human Serine/threonine-protein kinase Nek3 (NEK3)

Uniprot Id

P51956

Target Species

Human

Target Name

NEK3

Target Full Name

Serine/threonine-protein kinase Nek3

Target Function

Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin-mediated phosphorylation of PXN and VAV2. Implicated in prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells through mechanisms involving RAC1 activation and phosphorylation of PXN and VAV2.

Target Subcellular Location

Cytoplasm. Cell projection, axon.

Target Protein Families

Protein kinase superfamily, NEK Ser/Thr protein kinase family, NIMA subfamily

Target Tissue Specificity

Up-regulated in malignant versus normal breast tissue. Isoform 2 shows a high level of expression in testis, ovary and brain.

Target Synonyms

NEK3; Serine/threonine-protein kinase Nek3; EC 2.7.11.1; HSPK 36; Never in mitosis A-related kinase 3; NimA-related protein kinase 3

Target Background

This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. The kinase is activated by prolactin stimulation, leading to phosphorylation of VAV2 guanine nucleotide exchange factor, paxillin, and activation of the RAC1 GTPase. Two functional alleles for this gene have been identified in humans. The reference genome assembly (GRCh38) represents a functional allele that is associated with the inclusion of an additional coding exon in protein-coding transcripts, compared to an alternate functional allele that lacks the exon.