Recombinant Human Serine/threonine-protein phosphatase 6 regulatory subunit 3 (PPP6R3), Truncated

Uniprot Id

Q5H9R7

Target Species

Human

Target Name

PPP6R3

Target Full Name

Serine/threonine-protein phosphatase 6 regulatory subunit 3

Target Function

Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance.

Target Subcellular Location

Cytoplasm. Nucleus.

Target Protein Families

SAPS family

Target Tissue Specificity

Expressed in skeletal muscle, placenta, heart, pancreas, testis, brain, lung, liver, kidney, spleen, thymus, prostate, small intestine, colon and leukocytes.

Target Synonyms

C11orf23 ; Chromosome 11 open reading frame 23 ; KIAA1558; PP6R3 ; PP6R3_HUMAN; PPP6R3; Protein phosphatase 6 regulatory subunit 3 ; SAP190 ; SAPL ; SAPLa; SAPS domain family member 3; SAPS domain family; member 3; Serine/threonine-protein phosphatase 6 regulatory subunit 3; Sporulation induced transcript 4 associated protein SAPL; Sporulation-induced transcript 4-associated protein SAPL

Target Background

Protein phosphatase regulatory subunits, such as SAPS3, modulate the activity of protein phosphatase catalytic subunits by restricting substrate specificity, recruiting substrates, and determining the intracellular localization of the holoenzyme. SAPS3 is a regulatory subunit for the protein phosphatase-6 catalytic subunit (PPP6C; MIM 612725) (Stefansson and Brautigan, 2006 [PubMed 16769727]).