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| Cat.No | ACP00291 | Target Name | PGAM5 |
|---|---|---|---|
| Target Synonyms | Bcl-XL-binding protein v68;Phosphoglycerate mutase family member 5 | Form | Liquid or Lyophilized powder |
| Expression System | Yeast | Expression Range | 30-289aa |
| Mol Weight | 30.8 kDa | Protein Length | Partial |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q96HS1 |
|---|
Uniprot Id
Q96HS1
Target Species
Human
Target Name
PGAM5
Target Full Name
Serine/threonine-protein phosphatase PGAM5, mitochondrial
Target Function
Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2-dependent gene expression. Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore.
Target Subcellular Location
Mitochondrion outer membrane; Single-pass membrane protein. Note=Isoform 2 overexpression results in the formation of disconnected punctuate mitochondria distributed throughout the cytoplasm. Isoform 1 overexpression results in the clustering of mitochondria around the nucleus.
Target Protein Families
Phosphoglycerate mutase family, BPG-dependent PGAM subfamily
Target Research Area
Cancer
Target Synonyms
Bcl-XL-binding protein v68; BXLBv68; MGC5352; mitochondrial; PGAM5; PGAM5_HUMAN; Phosphoglycerate mutase family member 5; Serine/threonine protein phosphatase PGAM5 mitochondrial; Serine/threonine-protein phosphatase PGAM5
Target Background
Enables GTPase activator activity and protein serine/threonine phosphatase activity. Involved in necroptotic process. Located in mitochondrion.
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