Recombinant Human Serum amyloid P-component (APCS)

Uniprot Id

P02743

Target Species

Human

Target Name

APCS

Target Full Name

Serum amyloid P-component

Target Function

Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.

Target Involvement

SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits.

Target Subcellular Location

Secreted.

Target Protein Families

Pentraxin family

Target Tissue Specificity

Found in serum and urine.

Target Research Area

Cardiovascular

Target Synonyms

9.5S alpha 1 glycoprotein; 9.5S alpha-1-glycoprotein; Amyloid P component serum; APCS; MGC88159; Pentaxin related; Pentraxin 2; PTX 2; PTX2; SAMP_HUMAN; SAP; Serum Amyloid P; Serum amyloid P component; Serum amyloid P-component(1-203)

Target Background

The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo.